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Sheryl L. Fuller-Espie, Ph.D., DIC Biography: She was a postdoctoral research fellow at the Royal Postgraduate Medical School, Hammersmith Hospital, London, England, in the Immunology Department for seven years before moving back to the United States. Her second postdoctoral position and visiting professorship was completed at the Wistar Institute, Philadelphia, PA, and she has lived in the Philadelphia area since then. She is married to David Espie, a chemical engineer, and has two children, Daniel (at Pennsylvania State University)and Stephanie (North Penn High School). She began teaching full-time in 1996. She was at Arcadia University for two years before coming to Cabrini College where she is now Associate Professor of Biology in the Science Department. She has taught a wide variety of courses including Immunology, Microbiology, Theory & Practice in Biotechnology, Nutrition, Biological Sciences I & II, Animal Behavior, Biological Applications of Earth Science, Genetics, Virology, Special Problems, Honors Biology (Human Systems and Foreign Substances), Internship and Senior Seminar. Information about the courses taught by Dr. Fuller-Espie and her research program can be found at her faculty web page at http://pages.cabrini.edu/sfuller-espie. She has published in numerous peer-reviewed journals, has contributed chapters to textbooks in the fields of immunology and biotechnology, and writes textbook/testbank questions for medical textbooks in immunology and microbiology. She has an active undergraduate research lab and has published collaboratively with her research students. She was the Principal
Investigator (PI) for a National Science Foundation grant (CCLI-A&I)
titled: Development of an Undergraduate Laboratory-Based Biotechnology
Program for the Next-stage Post-Genomic Era ($169,052 including
institutional share) (January 2002-December 2004). She
was PI
for a Department of Education grant titled: Center for Science,
Education and Technology at Cabrini College: A Laboratory-Intensive
Undergraduate Biotechnology Program Model ($198,820) (June 2004-May
2005). Her publications include: Manuscripts: Fuller-Espie S.L.,
Nacarelli, T., Blake, E.L. & Bearoff, F.M. (2010) The effect of
oxidative stress on phagocytosis and apoptosis in the earthworm
Eisenia hortensis.
Invertebrate Survival Journal, 7: 89-106. Fuller-Espie, S.L.
(2010) Vertebrate cytokines interleukin 12 and gamma interferon, but not
interleukin 10, enhance phagocytosis in the annelid
Eisenia hortensis.
Journal of Invertebrate Pathology,
in press. Fuller-Espie, S.L.
(2010) Using Flow Cytometry to Measure Phagocytic Uptake in Earthworms.
Journal of Microbiology and
Biology Education, under review.
Goodfield, L. & Fuller-Espie, S.L
(faculty mentor). (2009) A flow cytometric analysis of the effects
of pathogen associated Molecular Patterns Peptidoglycan and Flagellin on
phagocytosis in the earthworm
Eisenia hortensis with enriched cell populations. [CD-ROM]
Proceedings for The National
Conference on Undergraduate Research, Asheville, pp. 53-61. Hill, K. &
Fuller-Espie, S.L. (faculty mentor) (2009) Effects of recombinant
human cytokines on the natural killer-like response in
Eisenia hortensis:
cytotoxicity of invertebrate effectors revealed using a non-radioactive
spectrophotometric assay. [CD-ROM]
Proceedings for The National Conference on Undergraduate Research,
Asheville, pp. 39-46. Goodfield, L. L. & Fuller-Espie, S.L. (2009) An Analysis of the effect of PAMPS on phagocytosis by enriched hyaline amoebocyte populations in the earthworm Eisenia hortensis. Cabrini College Journal of Undergraduate Research. Hill, K. M., & Fuller-Espie. S.L. (2009) Alteration of the natural killer-like response in Eisenia hortensis immunocytes after the treatment with recombinant human cytokines IL-10, IL-12, and gamma-IFN. Cabrini College Journal of Undergraduate Research.
DeRogatis, N. & Fuller-Espie, S.L. (2009) The in vitro effects of human pro-inflammatory cytokines granulocyte-macrophage colony stimulating factor and interleukin-1 b on natural killer-like responses in Eisenia hortensis. Cabrini College Journal of Undergraduate Research.
Goodfield, L., Hill, K., Grant, K., DeRogatis, N., & Fuller-Espie, S.L. (2009) The effect of pro-inflammatory cytokines
IL-1b,
IL-2, GM-CSF, and TNF-b on phagocytosis and
cell proliferation in Eisenia
hortensis.
Cabrini College Journal of Undergraduate Research.
Patel,
M. & Fuller-Espie, S.L. (2009) Investigation of effects of 7,12
dimethylbenz[a]-anthracene (DMBA) on cell-mediated cytotoxicity in
Eisenia fetida; an invertebrate model to study innate immune
responses. Cabrini College Journal of Undergraduate Research.
Fuller-Espie, S.L., Goodfield, L., Hill, K., Grant,
K. & DeRogatis, N. (2008) Conservation of cytokine-mediated responses in
innate immunity: a flow cytometric study investigating the effects of
human proinflammatory cytokines on phagocytosis in the earthworm
Eisenia hortensis.
Invertebrate Survival Journal, 5:124-134. Patel,
M., Francis, J., Cooper, E.L. & Fuller-Espie, S.L. (2007)
Development of a flow cytometric, non-radioactive cytotoxicity assay in
Eisenia fetida: An in vitro system designed
to analyze immunosuppression of natural killer-like coelomocytes in
response to 7, 12 dimethylbenz[a]anthracene (DMBA). European
Journal of Soil Biology,
43S1:S97-103.
Sudeesha Kunjibettu, Fuller-Espie
S, Carey GB, and Spain LM (2001) Conserved transmembrane tyrosine
residues of the TCR b
chain are required for TCR expression and function in primary T cells
and hybridomas.
International Immunology, 13:211-222.
Fuller-Espie S,
Hoffman Towler P, Wiest DL, Tietjen I, and Spain LM (1998) Transmembrane
polar residues of the TCR b chain are required for signal
transduction.
International Immunology.
10:923-933.
Fuller-Espie SL,
Murphy GA, Brett SJ, and Lechler RI (1997) Quantitative but not
qualitative variation in MHC class II alters CD4 interaction and
influences T cell repertoire formation.
Cellular Immunology.
177:49-61.
Lombardi G, Hargreaves, R, Sidhu S, Imami N, Lightstone L,
Fuller-Espie S, Ritter M, Robinson P, Tarnok A, and Lechler R (1996)
Antigen presentation by T cells inhibits IL-2 production and induces
IL-4 release due to altered cognate signals.
Journal of
Immunology 156:2769-2775.
Batten P, Heaton T,
Fuller-Espie S and Lechler R (1995) Human anti-mouse xenorecognition.
Provision of non-cognate interactions reveals plasticity of T
cell repertoire.
Journal of Immunology
155:1057-1065.
Klee H, Montoya A, Horodyski F, Lichtenstein C, Garfinkel D,
Fuller S, Flores C, Peschon JH,, Nester E and Gordon M (1984)
Nucleotide sequence of the tms genes of the pTiA6NC octopine Ti
plasmid: two gene products
involved in plant tumorigenesis.
Proceedings of the National
Academy of Science USA 81:1728-1732.
Lichtenstein C, Klee H, Montoya A, Garfinkel D,
Fuller S, Flores C, Nester E
and Gordon M (1984)
Nucleotide sequence and transcript mapping of the
tmr gene of the pTiA6NC octopine Ti plasmid:
a bacterial gene involved in plant tumorigenesis.
Journal of Molecular and
Applied Genetics 2:354-362.
Book Chapters and Related Material:
Fuller-Espie, S.L.,
contributor: (2010) Microbiology, A Clinical Approach,
Tony Strelkauskas, Jennifer Strelkauskas, and Danielle Strelkauskas,
Garland Science/Taylor & Francis Group, wrote OnlineTestbank for
ClasswireTM.
Fuller-Espie, S.L.,
contributor: (2009)
The Immune System, 3rd edition, Peter Parham, Garland
Science/Taylor & Francis Group, wrote end-of- chapter essay and multiple
choice questions and answers for this immunology textbook for advanced
undergraduates and medical school students, included USMLE-style
questions.
Fuller-Espie, S.L.,
contributor: (2009)
Classwire -
The Immune System, 3rd
edition, Peter Parham, Garland Science/Taylor & Francis Group wrote
OnlineTestbank for ClasswireTM.
Fuller-Espie, S.L.,
contributor: (2004)
The Immune System, 2nd
edition, Peter Parham, Garland Science/Taylor & Francis Group; wrote end
of chapter essay questions and answers for this immunology textbook for
advanced undergraduates and medical school students.
Fuller-Espie S,
Simpson E and Lechler R (2001) Major and minor transplantation antigens,
in Pathology and Immunology of
Transplantation and Rejection, (S Thiru and H Waldmann, eds)
Blackwell Scientific Publications, Ltd, Oxford, U.K., pp. 29-72.
Abstracts:
Goodfield, L. & Sheryl
Fuller-Espie (2009) A flow cytometric analysis of the effects of
PAMPs on phagocytosis in the earthworm
Eisenia hortensis with
enriched cell populations. Presented at the National Conference for
Undergraduate Research (NCUR), La Crosse Wisconsin. 2009 Proceedings of the National
Conference on Undergraduate Research.
Hill, K. M., & Fuller-Espie. S.L. (2009) Alteration of the natural killer-like
response in Eisenia hortensis
immunocytes after the treatment with recombinant human cytokines IL-10,
IL-12, and gamma-IFN. Presented at the 85th Annual
Meeting of the Pennsylvania Academy of Science, and at the 3rd
Annual Undergraduate Arts, Research & Scholarship Symposium, Cabrini College,
Radnor, PA. Pennsylvania Academy of Science 82:151.
Hill, K. M., & Fuller-Espie, S.L. (2009) Flow cytometric detection of
Eisenia hortensis coelomocyte-induced
apoptosis in human erythroleukemic K562 cells using magnetic bead
purification and annexin V staining. Presented at the 85th
Annual Meeting of the Pennsylvania Academy of Science. Pennsylvania
Academy of Science 82:151.
Hill, K. & Fuller-Espie, S.L.
(2009) Effects of recombinant human cytokines on the natural killer-like
response in Eisenia hortensis:
Cytotoxicity of invertebrate effectors revealed using a non-radioactive
spectrophotometric assay. Presented at the National Conference for
Undergraduate Research (NCUR), La Crosse Wisconsin.
2009 Proceedings of the National
Conference on Undergraduate Research.
Goodfield, L., Hill, K., Grant, K., DeRogatis, N., &
Fuller-Espie, S.L. (2008) Using Earthworms to study the Evolutionary
Conservation of Immune responses to Cytokines. Undergraduate Research at
the Capitol – Pennsylvania, Harrisburg, PA.
Goodfield, L., Hill, K., Grant, K., DeRogatis, N., &
Fuller-Espie, S.L. (2008) The effect of pro-inflammatory cytokines
IL-1b,
IL-2, GM-CSF, and TNF-a on phagocytosis and
cell proliferation in Eisenia
hortensis.
Journal of the Pennsylvania Academy of Science
81:118.
DeRogatis, N. & Fuller-Espie,
S.L. (2008)
The in vitro effects of human pro-inflammatory cytokines
granulocyte-macrophage colony stimulating factor and interleukin-1
b on natural killer-like responses in
Eisenia hortensis.
Second Annual
Undergraduate Arts, Research & Scholarship Symposium, Cabrini College,
Radnor, PA.
Goodfield, L., Grant, K., DeRogatis, N., Hill, K., and
Fuller-Espie, S.
(2008) Human Pro-inflammatory cytokines IL-1 β, IL-2, GM-CSF, and
TNF-α enhance phagocytosis in leukocytes of
Eisenia hortensis; A study
using flow cytometry and fluorescent
Escherichia coli as marker
cells.
Second Annual
Undergraduate Arts, Research & Scholarship Symposium, Cabrini College,
Radnor, PA.
Hill, K., Goodfield, L., DeRogatis, N., Grant, K., &
Fuller-Espie, S.L. (2008) Cell cycle analysis of coelomocytes from
Eisenia hortensis:
an invertebrate study investigating the effects of human
pro-inflammatory cytokines IL-1b,
GM-CSF, TNF-a
and IL-2 on cell proliferation .
Second Annual
Undergraduate Arts, Research & Scholarship Symposium, Cabrini College,
Radnor, PA. Patel,
M., Smith, M.R. & Fuller-Espie, S.L. (2007) Investigation of the
in vitro effects of 7,12 dimethylbenz[a]anthracene (DMBA) on
cell-mediated cytotoxicity in Eisenia fetida; an invertebrate
model to study innate immune responses. Journal of the
Pennsylvania Academy of Science 80:120-121.
Patel,
M. & Fuller-Espie, S.L. (2007) Effects of environmental
pollutants on natural killer-like activity in Eisenia fetida: an
invertebrate biomarker for the study of immunosuppression.
Presented at the 16th Annual Infection and Immunity Forum,
American Society for Microbiology, Drexel University School of Medicine,
Philadelphia, PA.
Patel,
M. & Fuller-Espie, S.L. (2007) Investigation of effects of 7,12
dimethylbenz[a]-anthracene (DMBA) on cell-mediated cytotoxicity in
Eisenia fetida; an invertebrate model to study innate immune
responses. Presented at the Undergraduate Arts, Research &
Scholarship Symposium, Cabrini College, Radnor, PA.
Patel,
M., Francis, J., Cooper, E.L. & Fuller-Espie, S.L. (2006)
Development of a flow cytometric, non-radioactive cytotoxicity assay in
Eisenia fetida: An in vitro system designed
to analyze immunosuppression of natural killer-like coelomocytes in
response to 7, 12 dimethylbenz[a]anthracene (DMBA). Presented at
the 8th International Symposium on Earthworm Ecology, Krakow,
Poland.
Fuller-Espie, S.
(2003) Biotechnology at Cabrini College:
Jellyfish, magnets and Cells that Glow.
Presented at the Blue Jeans Ball, Cabrini College.
Fuller-Espie S,
Hoffman-Towler P, Wiest DL, Tietjen I, and Spain LM (1996) Transmembrane
polar residues of the TCR 2B4 b
chain affect signal transduction and cytokine production.
Ninth Annual Retreat of the Graduate Group in Immunology,
University of Pennsylvania, The Wharton Sinkler Conference Center,
Chestnut Hill, Philadelphia, PA.
Fuller-Espie S,
Thomas J, Towler P and Spain L (1995)
Structure/function analysis of the T cell receptor:
RAG-1 blastocyst complementation utilizing transmembrane mutants
of the 2B4 b-chain.
Eight Annual Retreat of the Graduate Group in Immunology,
University of Pennsylvania, The Wharton Sinkler Conference Center,
Chestnut Hill, Philadelphia, PA.
Fuller-Espie S,
Murphy G, Brett SW and Lechler R (1994)
Selection of DR-restricted T
cells occurs in mice expressing hybrid human/mouse MHC class II
molecules. Second Annual
Congress of the British Society for Immunology,
Hilton RM, Fuller-Espie SL, Murphy G and Lechler R (1994)
Characterisation of mice transgenic for murine MHC class II on T cells.
Second Annual Congress of the British Society for Immunology,
Harrogate
Fuller-Espie S,
Greenlaw R, Barber L and Lechler R (1992) The staphylococcal enterotoxin
E superantigen binding site maps to the a-helix
of the b1
domain of HLA-DR. 8th
International Congress of Immunology, Budapest, Hungary.
Fuller-Espie SL,
Murphy GA, Barber LD, Batchelor JR and Lechler RI (1990) Investigation
of the role of MHC class II b2 domain:
CD4 interaction during positive selection in transgenic mice.
British Society for Immunology Meeting,
Fuller-Espie SL,
Murphy GA, Campagnoni C, Batchelor JR and Lechler RI (1990) Expression
of MBP in murine fibroblast and schwannoma cell lines for use in
generating MHC class I-restricted T cells.
European Federation of Immunological Societies,
Fuller SL,
Campagnoni CW, Glynn P, Batchelor JR and Lechler RI (1989) MHC class
I-restricted tolerance and immunity to the autoantigen myelin basic
protein: investigation using
MBP-transfected L cells. 7th
International Congress of
Fuller SL,
Campagnoni CW, Glynn P, Batchelor JR and Lechler RI (1989) MHC class
I-restricted tolerance and immunity to the autoantigen myelin basic
protein: investigation using
MBP-transfected L cells.
British Society for Immunology, Neuroimmunology Workshop, London,
England.
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