BIO 263 - Genetics
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Genetics

Genetics

BIO 263

Fall, 2008

Prerequisites:  BIO 101/102

 

Instructor:      David Dunbar, Ph.D.

Office:                        IC, Room 220

Telephone:     610-902-8770

Email:             ddunbar@cabrini.edu

 

 

Office Hours: Monday 11:15 – 12:15; Tuesday 6:00-7:00; Thursday 1:00 – 2:00

or by appointment.

 

Website:  Using a Web-browser (e.g., Netscape) access the following address:

http://cabrini.edu/science

 

Then follow the link for faculty and click on Dr. David Dunbar.  From there you will be directed to my homepage http://pages.cabrini.edu/ddunbar.  Click on my homepage and find BIO 263.  Here you will find lecture outline notes, assignments and study guides.

 

 

Textbooks:  Daniel L. Hartl and Elizabeth W. Jones (2005).  Genetics: Analysis of Genes and Genomes, 6th ed., Jones and Bartlett Publishers.

 

Bryan Sykes (2001).  The Seven Daughters of Eve, W.W. Norton & Company Publishers.

 

 

Course Description:  Genetics is designed to introduce students to classical genetics (the rules by which genes are transmitted), as well as molecular genetics (the structure of DNA and how it directs the structure of proteins).  In this course you will have to solve work problems, think experimentally, and make decisions about the information that you have learned.  Many of the skills that you learn in this course will be broadly applicable in other disciplines.  We also will be using Bryan Sykes’s best-selling book The Seven Daughters of Eve to reinforce concepts on mitochondrial inheritance in humans and how mitochondrial DNA can be used to study human evolution. 

 

 

Course Objectives:

After completing this course you should be able to:

-          understand and apply the material described in the above course description.

-          solve complex genetics problems.

-          define common genetics terminology.

-          interpret scientific articles presented in newspapers and scientific journals.

-          be aware of current events in genetics and human disease.

-          discuss how genetics is relevant to everyday life.

-          utilize and become competent at techniques used in a Genetics Lab.

-          appreciate how genetics can be used to trace human ancestry and human evolution.

 

As a result of this course, students will demonstrate:

● an understanding of the core principles of science and the interrelationships between science and other disciplines.

● an understanding of the impact of scientific discovery and technology on society.

● an understanding of the scientific method through laboratory experimentation and data analysis.

  scientific literacy and effective communication of scientific ideas.

 

 

This course outline is tentative and subject to change.

 

Lecture Outline

Lecture #        Date                Topic                                                  Reading

                                                                                                            Assignment

1                      8/26                 Intro. to Molecular Genetics &

                                                Genomics                                            Chapter 1

2                      8/28                 “                                                          “

3                      9/2                   “                                                          “

4                      9/4                   Transmission Genetics                        Chapter 3       

5                      9/9                   “                                                          “

6                      9/11                                                                             “                                 

7                      9/16                                                                             “

8                      9/18                 Sex Chromosome Inheritance             Chapter 4       

9                      9/23                                                                             “

10                    9/25                 “                                                          “

11                    9/30                 “                                                          “

12                    10/2                 Genetic Linkage & Genetic                Chapter 5

                                                Mapping                                              “                     

13                    10/7                 “                                                          “

14                    10/9                 “                                                          “                                 

                        10/14               Midterm Exam (100 pts.)

15                    10/16               Molecular Organization of

                                                Chromosomes                                     Chapter 7                   

16                    10/21               “                                                          “

17                    10/23               “                                                          “                     

18                    10/28               Human Karyotypes                             Chapter 8

19                    10/30               “                                                          “

20                    11/4                 “                                                          “                     

21                    11/6                 “                                                          “

22                    11/11               Genomics                                            Chapter 12

23                    11/13               “                                                          “

24                    11/18               Extranuclear Inheritance                     Chapter 16                 

25                    11/20               “                                                          “

26                    11/25               “                                                          “

27                    12/2                 “                                                          “

27                    12/4                 Final Exam Review

Final Exam (100 pts.)

 

 

 

 

Lab Outline

Lab #              Date                Topic

1                      8/28                 Measurements and Micropipetting

2                      9/4                   Mitosis/Meiosis

3                      9/11                 Fruit Fly Genetics

4                      9/18                 Fruit Fly Genetics, continued

5                      9/25                 Southern Blot Technique

6                      10/2                 Southern Blot Technique, continued

7                      10/9                 Lab Exam #1 (50 pts.)

8                      10/16               Human DNA PCR Analysis

9                      10/23               Human DNA PCR Analysis, continued

10                    10/30               Hardy-Weinberg Principle

11                    11/6                 Human Chromosome Analysis                      

12                    11/13               Yeast Genetics

                                                                         

13                    11/20               The Nucleosome Structure of Chromatin                              

14                    12/4                 Lab Exam #2 (50 pts.)                                              

 

Genetics paper due on Tuesday, December the 9th.                                  

 

 

Grading

Lecture Grade = 300 points

            Exams: 2 x 100 points each = 200 points

            Quizzes: 10 x 10 points each = 100 points

            Two lowest quiz grades will be dropped.

Lab Grade = 150 points

            Exams:  2 x 50 points each = 100 points

Genetics Paper Assignment = 50 points

 

To calculate your grade at the end of the semester, I will divide the total number of points you have by 450.  Your letter grade will be based on that number as a percentage according to the following scale:

       A  = 94.0-100%

A-    = 90-93.99%   C- = 70-72.99%

B+ = 87-89.99%   D+ = 67-69.99%

B = 83-86.99%      D = 60-66.99%

B-    = 80-82.99%   F = 59.99% or less

C+ = 77-79.99%

 

At the beginning of each week’s lecture (every Tuesday unless I state otherwise) you will be given a 10 point quiz based on the previous weeks lecture material.  You will have approximately 15 minutes to complete each lecture quiz and the entire class time to complete each exam, unless other arrangements have been made between you and your instructor.  Regular attendance is positively correlated with success in this and any course.  Laboratory attendance is mandatory.  For each unexcused laboratory absence five points will be deducted from your final overall point’s total.  Labs cannot be made up and you will earn a 0 on any lab assignment based on the material from the lab that was missed without a valid excuse. 

 

Exam and Assignment Dates:  Make-up quizzes and exams will only be offered for students with extreme circumstances.  Acceptable excuses include a major illness, family emergency or participation in a college-sponsored athletic competition.  All valid excuses must be documented with a note from the Academic Affairs Office, a physician, or a coach or a 0 grade will be assigned.  Assignments may be turned in late, but a 20% per day penalty will be assessed.  If the college is closed for any reason, exams will be held and assignments due during the next scheduled class period. 

 

Withdrawal Date:  The last day to withdraw from the course is Thursday November the 6th.

 

 

Human Genetics Book Paper Assignment:

 

  1. The first two pages of paper summarize the book.

 

 

  1. The second two pages of paper do a complete evaluation of the book including what you liked about the book and why and what you did not like about the book and why.

 

 

  1. The last two pages of paper describe how the book you have read connects with course content.  Specifically, how does the book connect to course learning outcomes 1) an appreciation of the core principles of the science of human genetics and the interrelationships between human genetics and other disciplines and 2) scientific literacy and effective communication of scientific ideas by reading selected books on human genetics and this particular writing assignment.

 

As well from your book reading, you are to write down 20 vocabulary words related to human genetics or genetics in general and define them.

 

Genetics paper is to be written in 12 point font, Roman Times with one inch margins.

ACADEMIC INTEGRITY

     Academic integrity is the pursuit of scholarly activity in an open, honest and responsible manner.  Consistent with this expectation, all students should act with personal integrity, respect other student’s dignity, rights and property, and help create and maintain an environment in which all can succeed through the fruits of their efforts.  Distractions such as unrelated conversations will not be tolerated.  Students will be asked to leave the room if their behavior is disruptive.  Academic dishonesty such as cheating and plagiarism will not be tolerated.  For the first offense, a grade of 0 without the possibility for a make-up will be given on the exam/work.  Failure of the course will occur for any subsequent offense.  Expulsion from the school may also result.  You have the right to contest a charge of academic dishonesty by submitting a request for an Academic Honesty Board hearing.

 

CABRINI COLLEGE ACADEMIC HONESTY POLICY

The principal objective of the Cabrini College Academic Honesty Policy is to encourage a dynamic, open and honest intellectual climate based on the personal and academic integrity of all members.  It is the responsibility of students to help maintain the community of academic integrity.  Students shall not receive credit for work that is not a product of their own efforts.  For a full description of the policy, please see the Academic Affairs homepage and follow the Academic Honesty link, or refer to the Cabrini College Undergraduate Catalog.

            Academic dishonesty includes, but is not limited to:

·         Plagiarism

·         Cheating

·         Information falsification or fabrication

·         Theft or destruction of intellectual property

·         Facilitation of academic dishonesty

For a first violation, the faculty member will meet with the student or otherwise communicate the charge.  The faculty member will complete an Academic Honesty Violation Charge Form, stating the violation and assigning a penalty.  The student should sign and date the charge form and return it to the faculty member.  The student may request a hearing before the Academic Honesty Board by indicating that option on the form.  For a second violation in a given course, the faculty member will follow the same procedures as in the first incident but will assign a penalty of failure of the course without privilege of withdrawal.  For any second or subsequent violation during a student’s academic career at Cabrini College the Academic Honesty Board shall conduct a hearing.

 

DISABILITITY SUPPORT SERVICES

Cabrini College provides support services and appropriate accommodations for qualified students with documented disabilities.  If you are a student who requires classroom or testing accommodations, please contact Disability Support Services in Founder’s Hall, room 97, or email at dss@cabrini.edu.  Please note that classroom or testing accommodations can only be provided to students who have Accommodations Notification Forms from Disability Support Services.  Students are responsible for providing the instructor with the Accommodation Notification Forms and informing the instructor when they need academic adjustments.

 

Good luck and enjoy the semester!